How does speciociliatine differ from mitragynine?

Speciociliatine and mitragynine share the same molecular formula and connectivity but differ in configuration at one or more stereocenters - they are diastereomers.

How abundant is speciociliatine in kratom leaf?

Published HPLC quantification places speciociliatine at approximately 0.8-1.5% of total alkaloid content, varying with strain and harvest.

Alkaloids & Chemistry

Speciociliatine

At-a-glance comparison

Spec	Value
Compound class	Indole alkaloid (corynantheine subclass)
Source	Secondary alkaloid in Mitragyna speciosa leaf
Relationship to mitragynine	Diastereomer (same molecular formula and connectivity, different configuration at one or more stereocenters)
Typical leaf abundance	Approximately 0.8-1.5% of total alkaloid content (varies by strain and harvest)
Reported pharmacological activity	Weak partial agonist at the mu-opioid receptor; in vitro receptor work generally reports lower MOR affinity than mitragynine

What is speciociliatine?

Speciociliatine is a secondary indole alkaloid in Mitragyna speciosa leaves. Structurally, it is a diastereomer of mitragynine, the two compounds share the same molecular formula and atomic connectivity but differ in configuration at one or more stereocenters. Speciociliatine is generally less abundant than mitragynine, paynantheine, or speciogynine; published HPLC quantification places it at approximately 0.8-1.5% of total alkaloid content, varying with strain and harvest.

Published in vitro receptor work characterizes speciociliatine as a weak partial agonist at the mu-opioid receptor. The compound's MOR binding affinity is lower than mitragynine's in published assay systems, and its functional efficacy at the receptor is correspondingly weaker. Speciociliatine has been included in multi-alkaloid receptor characterization studies of the kratom alkaloid family but has received less individual focus than mitragynine, 7-OH, or mitragynine pseudoindoxyl.

Common questions about speciociliatine

What is speciociliatine?: A secondary indole alkaloid in Mitragyna speciosa leaves, structurally a diastereomer of mitragynine and characterized in published in vitro work as a weak partial agonist at the mu-opioid receptor.
How does speciociliatine differ from mitragynine?: Speciociliatine and mitragynine share the same molecular formula and connectivity but differ in configuration at one or more stereocenters - they are diastereomers.
How abundant is speciociliatine in kratom leaf?: Published HPLC quantification places speciociliatine at approximately 0.8-1.5% of total alkaloid content, varying with strain and harvest.
What pharmacological activity has been reported for speciociliatine?: Published in vitro receptor work characterizes speciociliatine as a weak partial agonist at the mu-opioid receptor with lower binding affinity than mitragynine.

References

Brown PN, Lund JA, Murch SJ. (2017). A botanical, phytochemical and ethnomedicinal review of the genus Mitragyna korth. Journal of Ethnopharmacology.
Sharma A, Kamble SH, León F, et al. (2019). Simultaneous quantification of ten key Kratom alkaloids. Drug Testing and Analysis.
Obeng S, Kamble SH, Reeves ME, et al. (2019). Investigation of the adrenergic and opioid binding affinities, metabolic stability, plasma protein binding properties, and functional effects of selected indole-based kratom alkaloids. Journal of Medicinal Chemistry.

Important safety information:

Products containing 7-hydroxymitragynine (7-OH) are sold for adult use only (21+). These statements have not been evaluated by the U.S. Food and Drug Administration. Products are not intended to diagnose, treat, cure, or prevent any disease. The FDA has raised safety concerns regarding concentrated 7-OH products; consult a qualified healthcare professional before use. Do not operate vehicles or machinery after use. Keep out of reach of children and pets. Laws vary by state, buyers are responsible for knowing applicable law.