How does corynantheidine's receptor profile differ from mitragynine's?

Corynantheidine has been reported as a MOR antagonist or weak partial agonist, while mitragynine is a partial agonist with measurable functional efficacy. The compounds therefore lean in different directions on the agonist-antagonist spectrum.

How abundant is corynantheidine in kratom leaf?

Generally less than 1% of total alkaloid content. Corynantheidine is a minor alkaloid relative to mitragynine, paynantheine, and speciogynine.

Alkaloids & Chemistry

Corynantheidine

At-a-glance comparison

Spec	Value
Compound class	Indole alkaloid (eponymous compound of the corynantheine subclass)
Source	Minor alkaloid in Mitragyna speciosa leaf
Typical leaf abundance	Generally less than 1% of total alkaloid content
Distinguishing feature	Eponymous compound of the corynantheine structural subclass; minor leaf alkaloid in Mitragyna speciosa

What is corynantheidine?

Corynantheidine is a minor indole alkaloid present at low concentrations in the leaves of Mitragyna speciosa. The compound is the eponymous member of the corynantheine subclass of indole alkaloids - the structural family that includes mitragynine, paynantheine, speciogynine, and the secondary kratom alkaloids more broadly.

Corynantheidine is the eponymous compound of the corynantheine structural subclass and is one of several secondary indole alkaloids identified in Mitragyna speciosa leaf material in the natural-products chemistry literature.

Common questions about corynantheidine

What is corynantheidine?: A minor indole alkaloid in Mitragyna speciosa leaves, the eponymous compound of the corynantheine subclass. In vitro receptor work has characterized it as a mu-opioid receptor antagonist or weak partial agonist.
How does corynantheidine's receptor profile differ from mitragynine's?: Corynantheidine has been reported as a MOR antagonist or weak partial agonist, while mitragynine is a partial agonist with measurable functional efficacy. The compounds therefore lean in different directions on the agonist-antagonist spectrum.
How abundant is corynantheidine in kratom leaf?: Generally less than 1% of total alkaloid content. Corynantheidine is a minor alkaloid relative to mitragynine, paynantheine, and speciogynine.

References

Brown PN, Lund JA, Murch SJ. (2017). A botanical, phytochemical and ethnomedicinal review of the genus Mitragyna korth. Journal of Ethnopharmacology.
Sharma A, Kamble SH, León F, et al. (2019). Simultaneous quantification of ten key Kratom alkaloids. Drug Testing and Analysis.
Obeng S, Kamble SH, Reeves ME, et al. (2019). Investigation of the adrenergic and opioid binding affinities of selected indole-based kratom alkaloids. Journal of Medicinal Chemistry.

Important safety information:

Products containing 7-hydroxymitragynine (7-OH) are sold for adult use only (21+). These statements have not been evaluated by the U.S. Food and Drug Administration. Products are not intended to diagnose, treat, cure, or prevent any disease. The FDA has raised safety concerns regarding concentrated 7-OH products; consult a qualified healthcare professional before use. Do not operate vehicles or machinery after use. Keep out of reach of children and pets. Laws vary by state, buyers are responsible for knowing applicable law.